| Year: | 2006 |
| Other Titles: | 2006 Copa Toyota Libertadores de América 2006 Copa Toyota Libertadores da América |
| Dates: | January 24 - August 16 |
| Num Teams: | 38 |
| Associations: | 11 |
| Champion Other: |  Internacional |
| Count: | 1 |
| Second Other: | São Paulo |
| Matches: | 138 |
| Goals: | 386 |
| Top Scorer: | Fourteen players (5 goals each) |
| Player: | Fernandão[1] |
| Prevseason: | 2005 |
| Nextseason: | 2007 |
The 2006 Copa Toyota Libertadores was the 47th edition of the Copa Libertadores, CONMEBOL's annual football club tournament.
38 teams from 11 football associations took part, starting with the first qualifying round played on 24 January 2006.
Internacional won this edition for their first title, beating São Paulo 4–3 on aggregate.
Teams in the Team #1 column played at home in the first leg. |}
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6 winners from the qualifying round and the 26 pre-qualified clubs are drawn into 8 groups of 4 teams each. The top 2 teams in each group will advance to the Libertadores Cup play-offs.
Tiebreakers, if necessary, are applied in the following order:
The teams were seeded 1 to 8 (first placed teams of each group) and 9 to 16 (second placed teams of each group) and the ties were 1 vs 16, 2 vs 15, etc.
| Seed | Team | Pld | Pts | GD | Qualification |
|---|---|---|---|---|---|
| 1 |  Vélez Sársfield | 6 | 16 | +12 | Qualified as first place |
| 2 | Internacional | 6 | 14 | +9 | |
| 3 | Corinthians | 6 | 13 | +4 | |
| 4 | São Paulo | 6 | 12 | +6 | |
| 5 | Goiás | 6 | 11 | +6 | |
| 6 | Libertad | 6 | 11 | +5 | |
| 7 |  Atlético Nacional | 6 | 10 | +4 | |
| 8 | Santa Fe | 6 | 10 | +2 | |
| 9 |  Guadalajara | 6 | 12 | +3 | Qualified as second place |
| 10 |  LDU Quito | 6 | 10 | +7 | |
| 11 | UANL | 6 | 10 | +2 | |
| 12 | Estudiantes | 6 | 10 | 0 | |
| 13 | Palmeiras | 6 | 9 | +1 | |
| 14 | River Plate | 6 | 9 | +0 | |
| 15 | Nacional | 6 | 9 | +0 | |
| 16 | Newell's Old Boys | 6 | 8 | +0 |
| Teams | Scores | Tie-breakers | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 1st leg home team | 2nd leg home team | 1st leg | 2nd leg | ||||||
| Newell's Old Boys | 1 | 4 | Vélez Sársfield | 2 - 4 | 2 - 2 | - | - | - | |
| 1 | 4 | Internacional | 1 - 2 | 0 - 0 | - | - | - | ||
| River Plate | 6 | 0 | Corinthians | 3 - 2 | 3 - 1 | - | - | - | |
| Palmeiras | 1 | 4 | São Paulo | 1 - 1 | 1 - 2 | - | - | - | |
| Estudiantes | 3 | 3 | Goiás | 2 - 0 | 1 - 3 | 3 - 3 | 1 - 0 | - | |
| UANL | 2 | 2 | Libertad | 0 - 0 | 0 - 0 | 0 - 0 | 0 - 0 | 3 - 5 | |
| LDU Quito | 6 | 0 | Atlético Nacional | 4 - 0 | 1 - 0 | - | - | - | |
| Guadalajara | 3 | 3 | Santa Fe | 3 - 0 | 1 - 3 | 4 - 3 | - | - | |
| Teams | Scores | Tie-breakers | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 1st leg home team | 2nd leg home team | 1st leg | 2nd leg | ||||||
| Guadalajara | 2 | 1 | Vélez Sársfield | 0 - 0 | 2 - 1 | - | - | - | |
| LDU Quito | 2 | 3 | Internacional | 2 - 1 | 0 - 2 | 2 - 3 | - | - | |
| Estudiantes | 3 | 3 | São Paulo | 1 - 0 | 0 - 1 | 1 - 1 | 0 - 0 | 3 - 4 | |
| River Plate | 1 | 4 | Libertad | 2 - 2 | 1 - 3 | - | - | - | |
| Teams | Scores | Tie-breakers | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 1st leg home team | 2nd leg home team | 1st leg | 2nd leg | ||||||
| 1 | 4 | Internacional | 0 - 0 | 0 - 2 | - | - | - | ||
| Guadalajara | 0 | 6 | São Paulo | 0 - 1 | 0 - 3 | - | - | - | |
See main article: 2006 Copa Libertadores Finals.
