| Champ: |  Sofia Arvidsson |
| Runner: |  Marta Domachowska |
| Score: | 6–2, 2–6, 6–3 |
| Draw: | 32 |
| Seeds: | 8 |
See main article: 2006 Regions Morgan Keegan Championships and the Cellular South Cup.
Vera Zvonareva was the defending champion, but chose to compete in Dubai this week.
Sofia Arvidsson won the title by defeating Marta Domachowska 6–2, 2–6, 6–3 in the final.