| Year: | 2006 |
| Team: | Buffalo Bulls |
| Sport: | football |
| Conference: | Mid-American Conference |
| Division: | East Division |
| Short Conf: | MAC |
| Record: | 2–10 |
| Conf Record: | 1–7 |
| Head Coach: | Turner Gill |
| Hc Year: | 1st |
| Off Coach: | Gerald Carr |
| Oc Year: | 1st |
| Stadium: | University at Buffalo Stadium |
The 2006 Buffalo Bulls football team represented the University at Buffalo in the 2006 NCAA Division I FBS football season. The Bulls offense scored 220 points while the defense allowed 431 points. Turner Gill was in his first season as the Bulls head coach.
Due to a snow storm that hit the area, the game was played on Sunday instead of Saturday.