See main article: 2006 BNP Paribas Masters.
Nikolay Davydenko defeated Dominik Hrbatý in the final, 6–1, 6–2, 6–2 to win the singles tennis title at the 2006 Paris Masters.
Tomáš Berdych was the defending champion, but lost to Hrbatý in the quarterfinals.
A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated. All sixteen seeds received a bye into the second round.