The 2006 İstanbul Cup was a women's tennis tournament played on outdoor clay courts. It was the second edition of the İstanbul Cup, and part of the WTA Tier III tournaments of the 2006 WTA Tour. It was held in Istanbul from 22 through 28 May 2006. Fourth-seeded Shahar Pe'er won the singles title.
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q | width=85 | Q3 | width=85 | Q2 | width=85 | Q1 |
| Singles | 120 | 85 | 55 | 30 | 16 | 1 | 7.25 | 3.75 | 2.25 | 1 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 1 | 7.5 |
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q3 | width=85 | Q2 | width=85 | Q1 |
| Singles | $30,500 | $16,450 | $8,840 | $4,745 | $2,250 | $1,370 | $735 | $395 | $215 | |||
| Doubles * | $9,150 | $4,900 | $2,625 | $1,410 | $760 |
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Russian Federation | Anastasia Myskina | 13 | 1 | |
| Anna-Lena Grönefeld | 14 | 2 | ||
| Russian Federation | Anna Chakvetadze | 27 | 3 | |
 Israel | Shahar Pe'er | 32 | 4 | |
 India | Sania Mirza | 35 | 5 | |
 Colombia | Catalina Castaño | 37 | 6 | |
 Italy | Mara Santangelo | 40 | 7 | |
| Jelena Kostanić | 53 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Melinda Czink (gastroenteritis) Irina Kotkina (right elbow inflammation)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Anna-Lena Grönefeld |  United States | Meghann Shaughnessy | 15 | 1 | ||
| Italy | Maria Elena Camerin | Emmanuelle Gagliardi | 98 | 2 | ||
| Eleni Daniilidou | Jasmin Wöhr | 106 | 3 | |||
| United States | Ashley Harkleroad | United States | Bethanie Mattek | 150 | 4 |
The following pair received entry from the qualifying draw:
The following pair received entry as lucky losers:
Before the tournament
Melinda Czink (gastroenteritis) → replaced by Davydova/PanovaDuring the tournament
Ashley Harkleroad (right shoulder inflammation) Meghann Shaughnessy (right ankle sprain)See main article: article and 2006 İstanbul Cup – Singles.
Shahar Pe'er defeated Anastasia Myskina, 1–6, 6–3, 7–6(7–3)[1]It was the 3rd title for Pe'er in her singles career.
See main article: article and 2006 İstanbul Cup – Doubles.
Alona Bondarenko / 
Anastasiya Yakimova defeated Sania Mirza / 
Alicia Molik, 6–2, 6–4It was the 1st title for both Bondarenko and Yakimova in their respective doubles careers.
