| Sport: | football |
| Year: | 2005 |
| Team: | Wyoming Cowboys |
| Conference: | Mountain West Conference |
| Short Conf: | MW |
| Record: | 4 - 7 |
| Conf Record: | 2 - 6 |
| Hc Year: | 3rd |
| Off Coach: | Billy Cockhill |
| Oc Year: | 3rd |
| Def Coach: | Mike Breske |
| Dc Year: | 3rd |
The 2005 Wyoming Cowboys football team represented the University of Wyoming in the 2005 NCAA Division I-A football season. The team's head coach was Joe Glenn, who was in his third year at Wyoming. They played their home games at War Memorial Stadium in Laramie, Wyoming, and competed in the Mountain West Conference.