| Score: | 6–4, 6–2 |
| Draw: | 48 (5) |
| Seeds: | 16 |
See main article: 2005 Wimbledon Championships. Wayne and Cara Black were the defending champions but lost in the second round to Mahesh Bhupathi and Mary Pierce.
Bhupathi and Pierce defeated Paul Hanley and Tatiana Perebiynis in the final, 6–4, 6–2 to win the mixed doubles tennis title at the 2005 Wimbledon Championships.[1]
All seeds received a bye into the second round.
See also: 1 and 1. 
Bob Bryan / 
Rennae Stubbs (second round)
See also: 2 and 4. Wayne Black / Cara Black (second round)
See also: 3 and 2. 
Jonas Björkman / Lisa Raymond (semifinals)
See also: 4 and 3. Kevin Ullyett / Liezel Huber (semifinals)
See also: 5 and 2. Mike Bryan / Martina Navratilova (quarterfinals)
See also: 6 and 3. Todd Woodbridge / Samantha Stosur (quarterfinals)
See also: 7 and 1. 
Leoš Friedl / 
Janette Husárová (third round)
See also: 8 and 4. Mark Knowles / Venus Williams (third round)
See also: 9 and 2. Pavel Vízner / Nicole Pratt (second round)
See also: 10 and 3. Nenad Zimonjić / Katarina Srebotnik (third round)
See also: 11 and 1. Jared Palmer / Corina Morariu (second round)
See also: 12 and 4. 
Olivier Rochus / Kim Clijsters (quarterfinals)
See also: 13 and 3. 
Julian Knowle / Anna-Lena Grönefeld (third round)
See also: 14 and 1. Dominik Hrbatý / 
Elena Likhovtseva (third round)
See also: 15 and 4. Martin Damm / Květa Peschke (second round)
See also: 16 and 2. 
Andy Ram / 
Conchita Martínez (third round)