| Sport: | football |
| Year: | 2005 |
| Team: | Purdue Boilermakers |
| Conference: | Big Ten Conference |
| Short Conf: | Big Ten |
| Record: | 5–6 |
| Conf Record: | 3–5 |
| Hc Year: | 9th |
| Oc Year: | 9th |
| Dc Year: | 9th |
| Captain2: | Matt Turner |
| Captain3: | Brandon Villarreal |
| Captain4: | Jerod Void |
The 2005 Purdue Boilermakers football team represented Purdue University during the 2005 NCAA Division I-A football season. The team was coached by Joe Tiller and played its home games at Ross–Ade Stadium. Purdue played eleven games in the 2005 season, finishing with a 5–6 record and missing a post-season bowl game for the first time since 1996. Purdue was predicted by many as a dark horse for the Big Ten title, but after a strong 2–0 start, lost six straight before rebounding to finish a more respectable 5–6.
See also: 2005 Penn State Nittany Lions football team.
| Player | Position | Round | Pick | NFL club | |
| Safety | 2 | 54 | Kansas City Chiefs | ||
| Defensive Lineman | 4 | 127 | Minnesota Vikings | ||
| Defensive End | 5 | 135 | New Orleans Saints | ||
| Tight End | 5 | 167 | Pittsburgh Steelers |