| Year: | 2005 |
| Team: | Pittsburgh Panthers |
| Sport: | football |
| Conference: | Big East Conference |
| Short Conf: | Big East |
| Record: | 5–6 |
| Conf Record: | 4–3 |
| Head Coach: | Dave Wannstedt |
| Hc Year: | 1st |
| Off Coach: | Matt Cavanaugh |
| Oc Year: | 1st |
| Off Scheme: | Pro-style |
| Def Coach: | Paul Rhoads |
| Dc Year: | 6th |
| Def Scheme: | 4–3 |
| Stadium: | Heinz Field |
The 2005 Pittsburgh Panthers football team represented the University of Pittsburgh in the 2005 NCAA Division I-A football season.
| Player | Position | Round | Pick | NFL club | |
| Guard | 3 | 65 | Houston Texans | ||
| Defensive back | 6 | 174 | New Orleans Saints |