| Year: | 2005 |
| Team: | Michigan State Spartans |
| Conference: | Big Ten Conference |
| Short Conf: | Big Ten |
| Record: | 5–6 |
| Conf Record: | 2–6 |
| Hc Year: | 3rd |
| Oc Year: | 3rd |
| Def Coach: | Chris Smeland |
| Dc Year: | 3rd |
| Stadium: | Spartan Stadium (c. 75,005 natural grass) |
The 2005 Michigan State Spartans football team represented Michigan State University in the 2005 NCAA Division I-A football season. Michigan State competed as a member of the Big Ten Conference, and played their home games at Spartan Stadium in East Lansing, Michigan. The Spartans were led by third-year head coach John L. Smith.
The following players were selected in the 2006 NFL draft.
| Player | Round | Pick | Position | NFL Team |
|---|---|---|---|---|
| 3 | 97 | Safety | New York Jets | |
| 4 | 123 | Defensive Tackle | Cincinnati Bengals | |
| 7 | 214 | Center | Oakland Raiders | |