The women's 4 x 100 metres relay event at the 2005 European Athletics U23 Championships was held in Erfurt, Germany, at Steigerwaldstadion on 17 July.
| Gold | Natacha Vouaux Lina Jacques-Sébastien Aurélie Kamga Ayodelé Ikuesan  | |
| Silver | Karoline Köhler Verena Sailer Johanna Kedzierski Anne Möllinger | |
| Bronze | Claudia Baggio Doris Tomasini Alessia Berti Vincenza Calì  |
17 July
| Rank | Nation | Competitors | Time | Notes | ||
|---|---|---|---|---|---|---|
| align=left | | 44.22 | ||||
| align=left | 44.89 | |||||
| align=left | | 45.03 | ||||
| 4 | align=left | 45.45 | ||||
| 5 | align=left | 46.65 | ||||
| align=left |  | DNF | ||||
| align=left | DQ | IAAF rule 170.14 |
According to an unofficial count, 28 athletes from 7 countries participated in the event.
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