| Champ: |  Vera Zvonareva |
| Runner: |  Meghann Shaughnessy |
| Score: | 7–6(7–3), 6–2 |
| Draw: | 32 |
| Seeds: | 8 |
| Before Name: | Kroger St. Jude International |
See main article: 2005 Regions Morgan Keegan Championships and the Cellular South Cup.
Vera Zvonareva was the defending champion and successfully defended her title by defeating Meghann Shaughnessy 7–6(7–3), 6–2 in the final.