The 2005 Campionati Internazionali di Sicilia was a men's tennis tournaments played on outdoor clay courts in Palermo, Italy that was part of the International Series of the 2005 ATP Tour. It was the 27th edition of the tournament and was held from 26 September until 2 October 2005. Unseeded Igor Andreev won the singles title.
See main article: 2005 Campionati Internazionali di Sicilia – Singles. 
Igor Andreev defeated 
Filippo Volandri 0–6, 6–1, 6–3
See main article: 2005 Campionati Internazionali di Sicilia – Doubles. 
Martín García / Mariano Hood defeated 
Mariusz Fyrstenberg / Marcin Matkowski 6–2, 6–3