| Tourney Name: | CAF Champions League |
| Year: | 2005 |
| Other Titles: | Confederation of African Football Champions League |
| Size: | 130px |
| Dates: | 29 January – 12 November |
| Num Teams: | 52 |
| Confederations: | 47 |
| Champion Other: |  Al Ahly |
| Count: | 4 |
| Second Other: |  Étoile du Sahel |
| Matches: | 104 |
| Goals: | 266 |
| Top Scorer: | Mohamed Barakat Joetex Frimpong(7 goals each) |
| Prevseason: | 2004 |
| Nextseason: | 2006 |
The 2005 CAF Champions League was the 41st edition of the CAF Champions League, the Africa's premier club football tournament prize organized by the Confederation of African Football (CAF). It was started on 29 January 2005 with a preliminary round. Al Ahly of Egypt defeated Étoile du Sahel of Tunisia in the final to win their fourth title.
1 Wallidan FC were withdrawn by the Gambia Football Federation.
|Ajax Cape Town won 5–3 on penalties
|ASEC Mimosas won 5–3 on penalties|Ajax Cape Town won 3–2 on penalties
See main article: 2005 CAF Champions League group stage.
The first leg was played on 24–25 September and the second on 15–16 October.
See main article: 2005 CAF Champions League Final.
The top scorers from the 2005 CAF Champions League are as follows:
| Rank | Name | Team | Goals |
|---|---|---|---|
| 1 | Mohamed Barakat | Al Ahly | 7 |
| Joetex Frimpong | Enyimba | ||
| 3 | Emad Moteab | Al Ahly | 6 |
| 4 | Leonard Tsipa | CAPS United | 5 |
| 5 | Pamphil Rabefitia | USJF Ravinala | 4 |
| Collins Mbesuma | Kaizer Chiefs |