| Champ: |  Venus Williams |
| Runner: |  Nicole Vaidišová |
| Score: | 6–3, 6–2 |
| Draw: | 30 |
| Seeds: | 8 |
| Type: | singles doubles |
| Edition: | 1st |
See main article: 2005 İstanbul Cup. This was the first time a WTA level was held in Istanbul.Top seed Venus Williams won the title, defeating Nicole Vaidišová in the final, 6–3, 6–2.
The top two seeds received a bye into the second round.