| Season: | 2005–06 |
| League Topscorer: | 19 - Bohdan Yesyp (Naftovyk-Ukrnafta) |
| Nextseason: | 2006–07 |
The 2005–06 Ukrainian First League is the fifteenth since its establishment. There were 20 teams competing. Two teams were relegated from the 2004–05 Vyshcha Liha. Four teams were promoted from the 2004–05 Ukrainian Second League.
In 2005-06 season, the Ukrainian First League consists of the following teams:
These four teams were promoted from Druha Liha at the start of the season:
Two teams were relegated from the Vyshcha Liha season:
| Club | Coach | Replaced coach | |
|---|---|---|---|
| FC Bershad |  Serhiy Shevchenko | Anatoliy Murakhovskyi Vitaliy Sklyarenko | |
| Borysfen Boryspil | Stepan Matviyiv Pavlo Irichuk | ||
| CSKA Kyiv | Vasyl Yevseyev | ||
| Dynamo-2 Kyiv | |||
| Dynamo-Ihroservice Simferopol | Serhiy Lezhentsev | ||
| Enerhetyk Burshtyn | Mykhaylo Savka | ||
| Hazovyk-Skala Stryi | |||
| Helios Kharkiv | Volodymyr Shekhovtsov Rostyslav Lysenko | ||
| Karpaty Lviv | |||
| Krymteplitsia Molodizhne | Oleh Lutkov Anvar Suleimanov | ||
| Naftovyk-Ukrnafta Okhtyrka | |||
| Obolon Kyiv | Bohdan Blavatskyi | ||
| Podillya Khmelnytskyi | |||
| Shakhtar-2 Donetsk | |||
| Spartak Ivano-Frankivsk | Mykola Prystai | ||
| Spartak Sumy | Volodymyr Parkhomenko Valeriy Dushkov Valeriy Bermudes Viktor Ivanenko | ||
| Stal Dniprodzerzhynsk | |||
| Zorya Luhansk |
Statistics are taken from here.[1]
| Scorer | Goals (pen.) | Team | |
|---|---|---|---|
| Bohdan Yesyp | Naftovyk-Ukrnafta Okhtyrka | ||
| Mykola Bahlay | Hazovyk-Skala | ||
 Vadym Kyrylov | Zoria Luhansk | ||
| Pavlo Onysko | Krymteplytsia Molodizhne | ||
| Maksym Feshchuk | Karpaty Lviv | ||
| Valeriy Ivashchenko | Obolon Kyiv | ||
| Kostyantyn Vizyonok | Zoria Luhansk | ||
| Yevhen Seleznyov | Shakhtar-2 Donetsk | ||
| Serhiy Kucherenko | Podillya Khmelnytskyi | ||
| Bohdan Smishko | Zoria Luhansk |