| Competition: | Serie A |
| Season: | 2005–06 |
| Winners: | Internazionale 14th title |
| Dates: | 27 August 2005 – 14 May 2006 |
| Relegated: | Lecce Treviso Juventus |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Internazionale Roma Milan Chievo |
| Continentalcup2: | UEFA Cup |
| Continentalcup2 Qualifiers: | Palermo Livorno Parma |
| League Topscorer: | Luca Toni (31 goals) |
| Highest Scoring: | Roma 4–4 Chievo |
| Matches: | 380 |
| Total Goals: | 991 |
| Average Attendance: | 22,476 |
| Nextseason: | 2006–07 |
| Prevseason: | 2004–05 |
The 2005–06 Serie A (known as the Serie A TIM for sponsorship reasons) was the 104th season of top-tier Italian football, the 74th in a round-robin tournament. The league commenced on 28 August 2005 and finished on 14 May 2006. While Juventus were originally the first-placed team, this title was put sub judice due to their involvement in the Calciopoli scandal, with Internazionale instead declared champions by the Italian Football Federation (FIGC) on 26 July 2006, thus winning the title for the first time in 17 years.[1]
Prior to the 2005–06 season, if two or more teams were tied in points for first place, for only one spot in a European tournament, or in the relegation zone, teams would play tie-breaking matches after the season was over to determine which team would be champion, or be awarded a European tournament spot, or be saved or relegated. However, 2005–06 saw the introduction of new rules. If two or more teams ended the season with the same number of points, the ordering was determined by their head-to-head records. If two or more teams had the same total points and head-to-head records, goal difference became the decisive factor.
The Capocannoniere (top scorer) of 2005–06 was Luca Toni of Fiorentina. His 31 goals was the highest tally since Antonio Valentín Angelillo scored 33 for Internazionale in 1958–59.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Luca Toni | Fiorentina | 31 |
| 2 |  David Trezeguet | Juventus | 23 |
| 3 | David Suazo | Cagliari | 22 |
| 4 | Cristiano Lucarelli | Livorno | 19 |
| Francesco Tavano | Empoli | ||
| Milan | |||
| 7 | Alberto Gilardino | Milan | 17 |
| 8 | Tommaso Rocchi | Lazio | 16 |
| 9 |  Julio Cruz | Internazionale | 15 |
| Francesco Totti | Roma | ||
| 11 |  Kaká | Milan | 14 |
| 12 | Adriano | Internazionale | 13 |
| Sergio Pellissier | Chievo | ||
| Arturo Di Napoli | Messina |