| Competition: | NOFV-Oberliga |
| Season: | 2005–06 |
| Winners: | 1. FC Union Berlin, 1. FC Magdeburg |
| Promoted: | 1. FC Union Berlin, 1. FC Magdeburg |
| Relegated: | SV Falkensee-Finkenkrug, FC Anker Wismar, TSV Völpke, SV 1919 Grimma, FC Oberlausitz |
| League Topscorer: | Daniel Teixeira – 24 (1. FC Union Berlin) |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 season of the NOFV-Oberliga was the twelfth season of the league at tier four (IV) of the German football league system.
The NOFV-Oberliga was split into two divisions, NOFV-Oberliga Nord and NOFV-Oberliga Süd. The champions of each, 1. FC Union Berlin and 1. FC Magdeburg, were directly promoted to the 2006–07 Regionalliga Nord.
| Goals | Nat. | Player | Team | |
|---|---|---|---|---|
| 24 |  | Daniel Teixeira | 1. FC Union Berlin | |
| 19 |  | İbrahim Türkkan | SV Yeşilyurt | |
| 17 |  | Andreas Fricke | SV Babelsberg 03 |
| Goals | Nat. | Player | Team |
|---|---|---|---|
| 19 | | Christian Reimann | VFC Plauen |
| 17 | | Fait-Florian Banser | VfB Germania Halberstadt |
| Steffen Kellig | FSV Budissa Bautzen |