| Competition: | Cypriot Second Division |
| Season: | 2005–06 |
| Winners: | AEP (1st title) |
| Matches: | 182 |
| Total Goals: | 568 |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 Cypriot Second Division was the 51st season of the Cypriot second-level football league. AEP Paphos won their 1st title.
Fourteen teams participated in the 2005–06 Cypriot Second Division. All teams played against each other twice, once at their home and once away. The team with the most points at the end of the season crowned champions. The first three teams were promoted to 2006–07 Cypriot First Division and the last three teams were relegated to the 2006–07 Cypriot Third Division.
Teams promoted to 2005–06 Cypriot First Division
Teams relegated from 2004–05 Cypriot First Division
Teams promoted from 2004–05 Cypriot Third Division
Teams relegated to 2005–06 Cypriot Third Division