| Competition: | Belgian First Division |
| Season: | 2005–06 |
| Winners: | Anderlecht |
| Relegated: | La Louvière |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Anderlecht Standard Liège |
| Continentalcup2: | UEFA Cup |
| Continentalcup2 Qualifiers: | Club Brugge Zulte Waregem |
| League Topscorer: | Tosin Dosunmu (18 goals) |
| Matches: | 306 |
| Total Goals: | 769 |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 season of the Belgian Jupiler League began on August 5, 2005 and ended on May 5, 2006. Anderlecht won the title on the last day of competition.
These teams were promoted from the second division at the start of the season:
This team was relegated to the second division at the end of the season:
