During the 2005–06 season, Sampdoria dropped to 12th position in the Coppa Italia and failed to progress from the UEFA Cup's Group's stage.
| Club: | Sampdoria |
| Season: | 2005–06 |
| Manager: | Walter Novellino |
| League: | Serie A |
| League Result: | 12th |
| Cup1: | Coppa Italia |
| Cup1 Result: | Quarter-finals |
| Cup2: | UEFA Cup |
| Cup2 Result: | Group stage |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
Sampdoria's kit was manufactured by Kappa and sponsored by Erg.
Squad at end of season[1]
See main article: 2005–06 Serie A.