| Competition: | Tunisian Ligue Professionnelle 1 |
| Season: | 2005–06 |
| Winners: | Espérance de Tunis |
| Relegated: | Jendouba Sport, JS Kairouan |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Espérance de Tunis, Etoile du Sahel |
| Continentalcup2: | Confederation Cup |
| Continentalcup2 Qualifiers: | CS Sfaxien, EGS Gafsa |
| League Topscorer: | Amine Ltaïef (16 goals) |
| Biggest Home Win: | CSS 5–0 CSHL |
| Biggest Away Win: | EOGK 0–5 CSS |
| Highest Scoring: | CA 5–1 CSHL CSS 5–1 EGSG CSHL 3–3 CA EST 4–2 JSK JSK 3–3 CSHL |
| Matches: | 182 |
| Total Goals: | 356 |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 Tunisian Ligue Professionnelle 1 season was the 80th season of top-tier football in Tunisia.