| Season: | 2005–06 |
| Winners: | Hapoel Acre (1st title) |
| Nextseason: | 2006–07 |
The 2005–06 Toto Cup Leumit was the 17th time the cup was being contested. The final was played at Ramat Gan Stadium on 31 January 2006.
The winners were Hapoel Acre, beating Hapoel Be'er Sheva on penalties in the final after 0–0 in 120 minutes.