| Competition: | Slovenian Second League |
| Season: | 2005–06 |
| Winners: | Factor |
| League Topscorer: | Živojin Vidojević (15 goals) |
| Matches: | 135 |
| Total Goals: | 329 |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 Slovenian Second League season started on 14 August 2005 and ended on 3 June 2006. Each team played a total of 27 matches.