| Team: | San Miguel Beermen |
| Pbayear: | 2005–06 |
| Coach: | Jong Uichico |
| 1C-Name: | Fiesta Conference |
| 1C-Wins: | 8 |
| 1C-Losses: | 13 |
| 1C-Place: | 8th |
| 1C-Playoffs: | Wildcard |
| 2C-Name: | Philippine Cup |
| 2C-Wins: | 14 |
| 2C-Losses: | 10 |
| 2C-Place: | 4th |
| 2C-Playoffs: | Semifinals |
| Owners: | San Miguel Corporation |
| Manager: | Chito Loyzaga |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 San Miguel Beermen season was the 31st season of the franchise in the Philippine Basketball Association (PBA).
See main article: 2005 PBA Draft.
|- bgcolor="#edbebf"| 1| October 7| Talk 'N Text| 66–74| Hill (21)| | | Ynares Center| 0–1|- bgcolor="#edbebf"| 2| October 12| Coca Cola| 77–79| Seigle (27)| | | Ynares Center| 0–2|- bgcolor="#edbebf" | 3| October 16| Purefoods| 90–92 OT| Seigle (30)| | | Araneta Coliseum| 0–3|- bgcolor="#edbebf" | 4| October 23| Red Bull| 74–76| Hill (19)| | | Araneta Coliseum| 0–4|- bgcolor="#bbffbb" | 5| October 29| Air21| 123–119 (2OT) [1] | Hill (22)| | | Roxas City| 1–4|- bgcolor="#edbebf" | 6| November 2| Brgy.Ginebra| 72–74| Hill (20)| | | Cuneta Astrodome| 1–5|- bgcolor="#edbebf" | 7| November 9| Sta.Lucia| 82–85| Ildefonso (18)| | | Araneta Coliseum| 1–6|- bgcolor="#edbebf" | 8| November 11| Air21| 86–90| Johnson (19)| | | Araneta Coliseum| 1–7|- bgcolor="#edbebf" | 9| November 18| Sta.Lucia| 80–85| | | | Ynares Center| 1–8|- bgcolor="#bbffbb" | 10| December 2| Alaska| 66–62| | | | Araneta Coliseum| 2–8|- bgcolor="#bbffbb"| 11| December 6| Red Bull| 83–77 [2] | | | | Iloilo City| 3–8|- bgcolor="#bbffbb" | 12| December 9| Coca Cola| 90–76| Belasco (17)| | | Cuneta Astrodome| 4–8|- bgcolor="#bbffbb" | 13| December 11| Purefoods| 74–68| Seigle (23)| | | Ynares Center| 5–8|- bgcolor="#bbffbb" | 14| December 16| Brgy.Ginebra| 86–78| | | | Cuneta Astrodome| 6–8|- bgcolor="#edbebf"| 15| December 21| Alaska| | | | | Cuneta Astrodome| 6–9|- bgcolor="#edbebf"| 16| December 23| Talk 'N Text| 73–94| | | | Cuneta Astrodome| 6–10
| Player | Signed | Former team | |
| March 2006 | Air21 Express |
| Player | Signed | New team | |
| Eugene Tejada | March 2006 | Purefoods Chunkie Giants | |
| Anton Villoria | March 2006 | Talk 'N Text Phone Pals |