| Season: | 2005–06 |
| Stdtitle: | Ground |
| League Result: | 3rd |
| Cup1 Result: | 4th round |
| Cup2 Result: | Group Stage |
| League Topscorer: | Theofanis Gekas (15) |
| Season Topscorer: | Theofanis Gekas (15) |
| Highest Attendance: | 59,096 vs Olympiacos (28 August 2005) |
| Lowest Attendance: | 7,049 vs Kallithea (19 February 2006) |
| Average Attendance: | 21,883 |
| Pattern La1: | _nig06h |
| Pattern B1: | _shoulder_stripes_white_stripes |
| Pattern Ra1: | _nig06h |
| Pattern Sh1: | _adidaswhite |
| Pattern So1: | _3_stripes_white |
| Leftarm1: | 008000 |
| Body1: | 008000 |
| Rightarm1: | 008000 |
| Shorts1: | 008000 |
| Socks1: | 008000 |
| Pattern La2: | _nig06a |
| Pattern B2: | _shoulder_stripes_white_shirt |
| Pattern Ra2: | _nig06a |
| Pattern Sh2: | _adidasonwhite |
| Pattern So2: | _color_3_stripes_on_white |
| Leftarm2: | 008000 |
| Body2: | 008000 |
| Rightarm2: | 008000 |
| Shorts2: | 008000 |
| Socks2: | 008000 |
| Pattern La3: | _shoulder_stripes_white_stripes |
| Pattern B3: | _shoulder_stripes_white_stripes |
| Pattern Ra3: | _shoulder_stripes_white_stripes |
| Pattern Sh3: | _adidaswhite |
| Pattern So3: | _3_stripes_white |
| Leftarm3: | 003063 |
| Body3: | 003063 |
| Rightarm3: | 003063 |
| Shorts3: | 003063 |
| Socks3: | 003063 |
| Nextseason: | 2006–07 |
In the 2005–06 season Panathinaikos played for 47th consecutive time in Greece's top division, Alpha Ethniki. They also competed in UEFA Champions League and Greek Cup. Season started with Hans Backe as team manager.
See main article: 2005–06 Alpha Ethniki.
See main article: 2005–06 Greek Football Cup.
See main article: 2005–06 UEFA Champions League.
See main article: 2005–06 UEFA Champions League qualifying rounds.
See main article: 2005–06 UEFA Champions League group stage.