| Mode: | Basketball |
| Sex: | none |
| Year: | 2005–06 |
| Prev Year: | 2004–05 |
| Next Year: | 2006–07 |
| Team: | Northwestern State Demons |
| Conference: | Southland Conference |
| Short Conf: | Southland |
| Record: | 26–8 |
| Conf Record: | 15–1 |
| Head Coach: | Mike McConathy |
| Hc Year: | 7th |
| Asst Coach1: | Jeff Moore |
| Asst Coach2: | Bill Lewit |
| Asst Coach3: | Jacob Spielbauer |
| Stadium: | Prather Coliseum |
| Champion: | Southland Conference regular season champions Southland Conference tournament champions |
| Tourney: | NCAA tournament |
| Tourney Result: | Round of 32 |
The 2005–06 Northwestern State Demons basketball team represented Northwestern State University during the 2005–06 NCAA Division I men's basketball season. The Demons, led by 7th year head coach Mike McConathy, played their home games at Prather Coliseum and were members of the Southland Conference. They finished the season 26–8, 15–1 in Southland play to win the regular season title. They were champions of the Southland Conference tournament, winning the championship game over Stephen F. Austin, to earn an automatic bid to the 2006 NCAA tournament. As No. 14 seed in the Atlanta region, Northwestern State knocked off No. 3 seed Iowa by draining a corner three with time running out.[1] The Demons were then beaten by No. 6 seed West Virginia in the second round.[2]
[5],[6] |-!colspan=9 style=| Non-conference Regular season|-!colspan=9 style=| Southland Regular season|-!colspan=9 style=| 2006 Southland Conference tournament|-!colspan=9 style=|2006 NCAA tournament