The 2005–06 North West Counties Football League season was the 24th in the history of the North West Counties Football League, a football competition in England. Teams were divided into two divisions: Division One and Division Two.
| Competition: | North West Counties Football League Division One |
| Season: | 2005–06 |
| Winners: | Cammell Laird |
| Promoted: | Cammell Laird Skelmersdale United Alsager Town |
| Relegated: | None |
| Matches: | 462 |
| Total Goals: | 1507 |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
Division One featured two new teams:
| Competition: | North West Counties Football League Division Two |
| Season: | 2005–06 |
| Winners: | F.C. United of Manchester |
| Promoted: | F.C. United of Manchester Flixton Nelson |
| Relegated: | None |
| Matches: | 342 |
| Total Goals: | 1108 |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
Division Two featured two new teams: