| Competition: | National First Division |
| Season: | 2005–06 |
| Winners: | Wits University |
| Relegated: | FC Fortune Bloemfontein Young Tigers |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 National First Division (known as the Mvela Golden League for sponsorship reasons) was the 10th season of the National First Division, the second tier of South African soccer.
The champions were Wits University, who were promoted to the South African Premier Division.[1]
Bush Bucks, who finished 15th in the 2005–06 Premier Soccer League, were relegated to the 2006–07 National First Division----
Benoni Premier United were promoted to the 2006–07 Premier Soccer League.
Source:[2]