The 2005–06 Midland Football Combination season was the 69th in the history of Midland Football Combination, a football competition in England.
| Competition: | Midland Football Combination Premier Division |
| Season: | 2005–06 |
| Winners: | Atherstone Town |
| Promoted: | Atherstone Town |
| Matches: | 462 |
| Total Goals: | 1623 |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The Premier Division featured 19 clubs which competed in the division last season, along with three new clubs:
Also, Coventry Marconi changed name to Coventry Copsewood and Castle Vale KH changed name to Castle Vale.