| Season: | 2005–06 |
| Dates: | 5 August 2005 – 14 May 2006 |
| Competition: | Maltese Premier League |
| Winners: | Birkirkara (2nd title) |
| Relegated: | Mosta Ħamrun Spartans |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Birkirkara |
| Continentalcup2: | UEFA Cup |
| Continentalcup2 Qualifiers: | Sliema Wanderers Hibernians |
| Continentalcup3: | UEFA Intertoto Cup |
| Continentalcup3 Qualifiers: | Marsaxlokk |
| Matches: | 132 |
| Total Goals: | 440 |
| League Topscorer: | Michael Galea (19 goals) |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 Maltese Premier League (known as the BOV Premier League for sponsorship reasons) was the 26th season of the Maltese Premier League, and the 91st season of top-level league football in Malta. Birkirkara won the title while Mosta and Ħamrun Spartans were relegated to the Maltese First Division.
The following teams were promoted from the First Division at the start of the season:
From the previous Premier League season, the following teams were relegated to the First Division:
The teams placed in the first six positions in the league table qualified for the Top Six, and the points obtained during the first phase were halved (and rounded up) before the start of second phase. As a result, the teams started with the following points before the second phase: Birkirkara 21 points, Sliema Wanderers 20, Hibernians 19, Marsaxlokk 17, Valletta 12 and Msida Saint-Joseph 11.
The teams which finished in the last four league positions were placed in the play-out and at the end of the phase the two lowest-placed teams were relegated to the First Division. The points obtained during the first phase were halved (and rounded up) before the start of second phase. As a result, the teams started with the following points before the second phase: Floriana 10 points, Ħamrun Spartans 10, Pietà Hotspurs 8, Mosta 4.
| Rank | Player | Club | Goals[1] |
|---|---|---|---|
| 1 |  Michael Galea | Birkirkara | 19 |
| 2 |  Daniel Nwoke | Msida Saint-Joseph | 16 |
| Ivan Woods | Sliema Wanderers | ||
| 4 | Adrian Mifsud | Floriana | 15 |
| 5 | Etienne Barbara | Birkirkara | 14 |
| Andrew Cohen | Hibernians | ||
 Wendell Gomes | Marsaxlokk | ||
| 8 | Danilo Dončić | Sliema Wanderers | 13 |
| 9 | Ikechukwu Chibueze | Mosta | 12 |
| Cleavon Frendo | Marsaxlokk |