| Season: | 2005–06 |
| League Topscorer: | Chima Dozie (15) |
| Total Goals: | 251 |
| Average Goals: | 2.78 |
| Nextseason: | 2006–07 |
The 2005–06 Maltese First Division (known as 2005–06 BOV First Division for sponsorship reasons) started on 10 September 2005 and finished on 14 May 2006. Lija Athletic and St. Patrick were the teams which were relegated from the 2004–05 Maltese Premier League. Tarxien Rainbows and St.Andrews were the promoted teams. St. Georges were the champions and Marsa were the runners-up. Both were promoted to the Premier League. Lija Athletic and St. Andrews were relegated. This was two straight relegations for Lija while St. Andrews were sent back down having just been promoted.
The Maltese First Division 2005–06 was made up of these teams:
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Chima Dozie | Naxxar Lions | 15 |
| 2 |  Mark Tanti | St. Patrick | 11 |
| 3 | Gilbert Martin | Marsa | 10 |
| 4 | Uchenna Anywanna | Mqabba | 9 |
| 5 | Karl Sciberras | San Ġwann | 8 |
| Anthony Ewurum | St. George's |