| Mode: | Basketball |
| Year: | 2005–06 |
| Team: | Louisville Cardinals |
| Conference: | Big East Conference (1979–2013) |
| Short Conf: | Big East |
| Record: | 21–13 |
| Conf Record: | 6–10 |
| Hc Year: | 5th |
| Arena: | Freedom Hall |
The 2005–06 Louisville Cardinals men's basketball team represented the University of Louisville in the 2005 - 06 NCAA Division I men's basketball season. The head coach was Rick Pitino[1] and the team finished the season with an overall record of 21–13.[2]