The 2005–06 Liga de Fútbol Profesional Boliviano was the first Bolivian football league to use the European calendar format. However, it was quickly changed after issues with relegation occurring in the middle of the season instead of the end.
The first part of the season was divided into two groups. The top three of each group advanced to a final group stage known as the Hexagonal Final.
Due to issues with the second division and changing to the European season format, a relegation was held in the middle of the season between the Apertura and Clausura. Universidad Iberoamericana was relegated and Destroyers played a promotion relegation playoff against Guabirá. Universitario was promoted to the Torneo Clausura.
| Pos | Name | Team | Goals | |
|---|---|---|---|---|
| 1 | Cristino Jara | Real Potosí | 16 | |
| 2 | José Alfredo Castillo | Oriente Petrolero | 13 | |
| 3 | Carlos Monteiro | Real Potosí | 11 | |
| 4 | Martín Menacho | Bolívar | 10 | |
| 5 | Gualberto Mojica | Blooming | 9 | |
| Juan Daniel Salaberry | Universitario de Sucre | 9 |