| Mode: | Basketball |
| Sex: | none |
| Year: | 2005–06 |
| Team: | Hampton Pirates |
| Conference: | Mid-Eastern Athletic Conference |
| Short Conf: | MEAC |
| Record: | 16–16 |
| Conf Record: | 10–8 |
| Hc Year: | 4th |
| Champion: | MEAC tournament champions |
| Tourney Result: | first round |
The 2005–06 Hampton Pirates men's basketball team represented Hampton University during the 2005–06 NCAA Division I men's basketball season. The Pirates were members of the Mid-Eastern Athletic Conference and were coached by Bobby Collins, his fourth and final year as head coach. The Pirates played home games at the Hampton Convocation Center.
Hampton finished the season with 16–16 record and an 10–8 MEAC record. The Pirates won the MEAC tournament to earn the conference's automatic bid to the NCAA tournament. Playing as one of two No. 16 seeds in the Midwest region, Hampton was beaten by fellow No. 16 seed Monmouth, 71–49,[1] in the Play-in round.
|-!colspan=9 style=| Regular season|-!colspan=9 style=| MEAC tournament|-!colspan=9 style=| NCAA tournament|-[3]