| Competition: | Macedonian First League |
| Season: | 2005–06 |
| Winners: | Rabotnichki 2nd domestic title |
| Relegated: | Cementarnica Belasica |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Rabotnichki |
| Continentalcup2: | UEFA Cup |
| Continentalcup2 Qualifiers: | Makedonija G.P. Vardar |
| Continentalcup3: | Intertoto Cup |
| Continentalcup3 Qualifiers: | Pobeda |
| League Topscorer: | Stevica Ristić (27 goals) |
| Dates: | 5 August 2005 – 21 May 2006 |
| Biggest Home Win: | Bashkimi 6–0 Belasica |
| Biggest Away Win: | Bregalnica 0–4 Makedonija |
| Highest Scoring: | Belasica 4–6 Sileks |
| Matches: | 198 |
| Total Goals: | 564 |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 Macedonian First League was the 14th season of the Macedonian First Football League, the highest football league of Macedonia. The first matches of the season were played on 5 August 2005 and the last on 21 May 2006. Rabotnichki defended their championship title, having won their second title in a row.
Relegated to 2005–06 Second League
|
Relegated to 2006–07 Second League
|
| Club | City | Stadium | Capacity | |
|---|---|---|---|---|
| Bashkimi | Kumanovo | Gradski stadion Kumanovo | 7,000 | |
| Belasica | Strumica | Stadion Mladost | 6,370 | |
| Bregalnica Kraun | Shtip | Gradski stadion Shtip | 4,000 | |
| Cementarnica 55 | Skopje | Stadion Cementarnica | 2,000 | |
| Makedonija G.P. | Skopje | Stadion Gjorche Petrov | 3,000 | |
| Pobeda | Prilep | Stadion Goce Delchev | 15,000 | |
| Rabotnichki Kometal | Skopje | Gradski stadion Skopje | 18,104 | |
| Renova | Djepchishte | Gradski stadion Tetovo | 15,000 | |
| Shkëndija 79 | Tetovo | Gradski stadion Tetovo | 15,000 | |
| Sileks | Kratovo | Stadion Sileks | 5,000 | |
| Vardar | Skopje | Gradski stadion Skopje | 18,104 | |
| Vëllazërimi | Kichevo | Gradski stadion Kichevo | 5,000 |
Every team will play three times against each other team for a total of 33 matches. The first 22 matchdays will consist of a regular double round-robin schedule. The league standings at this point will then be used to determine the games for the last 11 matchdays.
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| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Stevica Ristić | Sileks | 27 |
| 2 | Filip Ivanovski | Makedonija G.P. | 22 |
| 3 | Riste Naumov | Vardar | 15 |
| 4 | Aleksandar Toleski | Cementarnica | 14 |