| Club: | Metalist Kharkiv |
| Season: | 2005–06 |
| Manager: | Myron Markevych |
| Chairman: | Oleksandr Yaroslavskyi |
| Stadium: | OSC Metalist |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 season is FC Metalist Kharkiv's 61st season in existence and the club's 2nd consecutive season in the top flight of Ukrainian football. In addition to the domestic league, Metalist Kharkiv participated in that season's edition of the Ukrainian Cup. The season covers the period from 1 July 2005 to 30 June 2006.
Squad at end of season
See main article: article and 2005–06 Vyshcha Liha.
See main article: article and 2005–06 Ukrainian Cup.