| Mode: | Women's Basketball |
| Year: | 2005–06 |
| Team: | Duke Blue Devils |
| Conference: | Atlantic Coast Conference |
| Short Conf: | ACC |
| Coachrank: | 2 |
| Aprank: | 4 |
| Record: | 31–4 |
| Conf Record: | 12–2 |
| Hc Year: | 14th |
| Ac1 Year: | 1st |
| Asst Coach2: | Shannon Perry |
| Asst Coach3: | Gale Valley |
| Tourney Result: | Runner-up |
The 2005–06 Duke Blue Devils women's basketball team represented Duke University during the 2005–06 NCAA Division I women's basketball season. The team was led by head coach Gail Goestenkors in her 14th season at the school, and played its home games at Cameron Indoor Stadium in Durham, North Carolina as members of the Atlantic Coast Conference. They finished the season 31–4, 12–2 in ACC play to finish second in the regular season conference standings. They were defeated in the ACC tournament but received an at-large bid to the NCAA tournament. Playing as No. 1 seed in the Bridgeport region (East), the Blue Devils defeated Southern, USC, Michigan State, and UConn to reach the Final Four for the third time in five years. Duke was one of three ACC schools to play in the 2006 Final Four, joining North Carolina and Maryland. In the National semifinal round, the Blue Devils easily defeated LSU to advance to the National championship game where the team was beaten by conference foe Maryland, 78–75 in overtime.
|-!colspan=12 style=| Regular season|-!colspan=12 style=| ACC tournament|-!colspan=12 style=| NCAA tournamentSource[1]
See main article: 2005–06 NCAA Division I women's basketball rankings.