| Competition: | Cypriot Fourth Division |
| Winners: | Anagennisi G. (1st title) |
| Promoted: | Anagennisi G. Olympos Episkopi |
| Relegated: | Kissos Elia Ellinismos |
| Matches: | 182 |
| Total Goals: | 554 |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
| Season: | 2005–06 |
The 2005–06 Cypriot Fourth Division was the 21st season of the Cypriot fourth-level football league. Anagennisi Germasogeias won their 1st title.
Fourteen teams participated in the 2005–06 Cypriot Fourth Division. All teams played against each other twice, once at their home and once away. The team with the most points at the end of the season crowned champions. The first three teams were promoted to the 2006–07 Cypriot Third Division and the last three teams were relegated to regional leagues.
Teams received three points for a win, one point for a draw and zero points for a loss.
Teams promoted to 2005–06 Cypriot Third Division
Teams relegated from 2004–05 Cypriot Third Division
1AEK/Achilleas Ayiou Theraponta withdrew from the 2005–06 Cypriot Fourth Division.
Teams promoted from regional leagues
Teams relegated to regional leagues