| Competition: | Cypriot First Division |
| Season: | 2005–06 |
| Winners: | Apollon (3rd title) |
| Relegated: | APOP APEP THOI |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Apollon (1st qualifying round) |
| Continentalcup2: | UEFA Cup |
| Continentalcup2 Qualifiers: | Omonia (1st qualifying round) APOEL (1st qualifying round; via Cypriot Cup)) |
| Continentalcup3: | Intertoto Cup |
| Continentalcup3 Qualifiers: | Ethnikos (1st round) |
| League Topscorer: | Łukasz Sosin (28 goals)[1] |
| Matches: | 182 |
| Total Goals: | 603 |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 Cypriot First Division was the 67th season of the Cypriot top-level football league. Apollon won their 3rd title.
Fourteen teams participated in the 2005–06 Cypriot First Division. All teams played against each other twice, once at their home and once away. The team with the most points at the end of the season crowned champions. The last three teams were relegated to the 2006–07 Cypriot Second Division.
The champions ensured their participation in the 2006–07 UEFA Champions League and the runners-up in the 2006–07 UEFA Cup.
The teams had to declare their interest to participate in the 2006 UEFA Intertoto Cup before the end of the championship. At the end of the championship, the higher placed team among the interested ones participated in the Intertoto Cup (if they had not secured their participation in any other UEFA competition).
Teams received three points for a win, one point for a draw and zero points for a loss.
AEP Paphos, Alki Larnaca and Aris Limassol were relegated from previous season and played in the 2005–06 Cypriot Second Division. They were replaced by the first three teams of the 2004–05 Cypriot Second Division, APOP Kinyras, APEP and THOI Lakatamia.