| Mode: | women's basketball |
| Year: | 2005–06 |
| Team: | Clemson Tigers |
| Conference: | Atlantic Coast Conference |
| Short Conf: | ACC |
| Record: | 8–21 |
| Conf Record: | 2–12 |
| Hc Year: | 1st |
The 2005–06 Clemson Tigers women's basketball team represented Clemson University during the 2005–06 NCAA Division I women's basketball season. The Tigers were led by first year head coach Cristy McKinney. The Tigers, members of the Atlantic Coast Conference, played their home games at Littlejohn Coliseum.
|- !colspan=9 style=""| ACC Tournament