| Competition: | Beta Ethniki |
| Season: | 2005–06 |
| Winners: | Ergotelis |
| Promoted: | Ergotelis Kerkyra Aris |
| Relegated: | ASK Olympiacos Panachaiki Paniliakos |
| Matches: | 306 |
| Total Goals: | 653 |
| Biggest Home Win: | PAS Giannina 5–0 Veria PAS Giannina 5–0 Diagoras |
| Biggest Away Win: | Agrotikos Asteras 1–4 Kallithea |
| Highest Scoring: | Eth. Asteras 4–3 Diagoras Ethnikos 4–3 Kallithea --> |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
Beta Ethniki 2005–06 complete season.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 |  Patrick Ogunsoto | Ergotelis | 21 |
| 2 |  Ilias Kampas | Ilisiakos | 15 |
| 3 | Georgios Saitiotis | Niki Volos | 13 |
| 4 | Thanasis Gogas | Panserraikos | 13 |
| 5 | Ljubiša Savić | ASK Olympiacos | 11 |
| Ethnikos Asteras | |||
| 7 |  Leonardo | Thrasyvoulos | 10 |
| 8 | Christos Mitsis | Ethnikos Asteras | 9 |
| Georgios Lanaris | Veria | ||
| Ederson Fofonka | Kerkyra |