| Fromdate: | 24 February |
| Todate: | 4 March 2006 |
| Administrator: | Pakistan Cricket Board |
| Cricket Format: | Twenty20 |
| Tournament Format: | Round-robin and knockout |
| Host: |  Karachi |
| Count: | 1 |
| Participants: | 13 |
| Matches: | 39 |
| Previous Year: | 2004–05 |
| Previous Tournament: | 2004–05 ABN-AMRO Twenty-20 Cup |
| Next Year: | 2006–07 |
| Next Tournament: | 2006–07 ABN-AMRO Twenty-20 Cup |
The 2005–06 ABN-AMRO Twenty-20 Cup was the second season of the ABN-AMRO Twenty-20 Cup in Pakistan, sponsored by ABN AMRO. It was held in Karachi from 24 February to 4 March 2006. This edition featured an expanded format, with an increase from 19 to 39 matches and from 11 to 13 teams; the new teams being the Islamabad Leopards and the Abbottabad Rhinos. The Sialkot Stallions won the tournament by defeating the defending champions the Faisalabad Wolves in the final.
The 13 teams are divided into two groups: Pool A with seven teams and Pool B with six. Each group plays a single round-robin tournament and the top two teams from each group advance to the semi-finals. The winners of each group play the runners-up of the other group in the semi-finals. The winners of the semi-finals play the final.[1]
| Points | ||
| Won | 2 points | |
| No result | 1 point | |
| Loss | 0 points |
The position of the teams in the points table is determined by:
The top two teams from each group qualify for the semi-finals.
| 6 | 6 | 0 | 0 | 12 | +2.099 | ||
| 6 | 4 | 2 | 0 | 8 | +2.686 | ||
| 6 | 3 | 3 | 0 | 6 | +0.077 | ||
| 6 | 3 | 3 | 0 | 6 | +0.003 | ||
| 6 | 3 | 3 | 0 | 6 | –1.431 | ||
| 6 | 1 | 5 | 0 | 2 | –1.438 | ||
| 6 | 1 | 5 | 0 | 2 | –2.268 |
| 5 | 5 | 0 | 0 | 10 | +1.719 | ||
| 5 | 4 | 1 | 0 | 8 | +0.871 | ||
| 5 | 2 | 3 | 0 | 4 | +0.130 | ||
| 5 | 2 | 3 | 0 | 4 | –0.250 | ||
| 5 | 2 | 3 | 0 | 4 | –0.492 | ||
| 5 | 0 | 5 | 0 | 0 | –1.779 |
Qualified for semi-finals
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Ten Sports was covering the tournament until a bomb blast in Karachi. PTV 1 covered some of the remaining matches afterwards.