| Club: | 1. FC Kaiserslautern |
| Season: | 2005–06 |
| Manager: | Michael Henke (until 19 November) Wolfgang Wolf (from 21 November) |
| Stadium: | Fritz-Walter-Stadion |
| League: | Bundesliga |
| League Result: | 16th (relegated) |
| Cup1: | DFB-Pokal |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Halil Altıntop (20) |
| Season Topscorer: | Halil Altıntop (21) |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
During the 2005–06 German football season, 1. FC Kaiserslautern competed in the Bundesliga.
Michael Henke failed to replicate his success as Bayern Munich assistant manager and was soon sacked with Kaiserslautern in relegation danger. Wolfgang Wolf was unable to arrest the decline and Kaiserslautern's 9-year stay in the Bundesliga - which had seen a Champions League quarter-final, UEFA Cup semi-final, DFB-Pokal final, and a league title - came to an end.
Squad at end of season[1]