The 2004 Palm Beach Gardens Challenger was a women's professional tennis tournament played on clay courts. It was the 2nd edition of the Palm Beach Gardens Challenger, and was an ITF $50,000 tournament from 2003 to 2005. It took place at the Palm Beach Gardens Tennis Center in Florida from November 29 to Dec 5, 2004.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Anna-Lena Grönefeld | 43 | 1 | ||
 United States | Lilia Osterloh | 61 | 2 | |
 Kazakhstan | Sessil Karatantcheva | 72 | 3 | |
| United States | Kelly McCain | 76 | 4 | |
 Hungary | Melinda Czink | 95 | 5 | |
 Venezuela, Bolivarian Republic of | Milagros Sequera | 110 | 6 | |
 India | Shikha Uberoi | 112 | 7 | |
 Romania | Edina Gallovits | 133 | 8 |
The following players received wildcards into the singles main draw:
Megan Falcon Carly Gullickson Milangela MoralesThe following players received entry from the qualifying draw:
The following players received entry via the Lucky loser spot:
Sessil Karatantcheva def. Sania Mirza, 3–6, 6–2, 7–5.
Līga Dekmeijere / 
Nana Miyagi def. Kelly McCain / Kaysie Smashey, 6–3, 6–2.
