| Score: | 4–6, 6–4, 7–5 |
| Draw: | 30 |
| Seeds: | 8 |
See main article: 2004 Kroger St. Jude International and the Cellular South Cup.
Lisa Raymond was the defending champion, but lost in the final to Vera Zvonareva. The score was 4–6, 6–4, 7–5.
The first two seeds received a bye into the second round.