See main article: 2003 Family Circle Cup.
Justine Henin-Hardenne defeated Serena Williams in the final, 6–3, 6–4 to win the singles tennis title at the 2003 Family Circle Cup. It was her second title of the year, and the eighth of her career.
Iva Majoli was the defending champion, but lost in second round to Elena Dementieva.
The first nine seeds received a bye into the second round.