| Team: | Buffalo Destroyers |
| Year: | 2003 |
| Record: | 5–11 |
| Division Place: | 4th |
| Coach: | Ron Selesky |
| Stadium: | HSBC Arena |
| Playoffs: | did not qualify |
| Shortnavlink: | Destroyers seasons |
The 2003 Buffalo Destroyers season was the 5th season for the franchise and the 5th in Buffalo, New York. They finished with a 5–11 record and failed to qualify for the playoffs.
Ron Selesky started his first season as head coach of the Destroyers.
| Week | Date | Opponent | Home/Away | Result | |
|---|---|---|---|---|---|
| 1 | February 1 | Grand Rapids Rampage | Home | L 36–54[1] | |
| 2 | February 9 | Carolina Cobras | Home | W 44–16[2] | |
| 3 | February 14 | Arizona Rattlers | Home | W 49–45[3] | |
| 4 | February 22 | Georgia Force | Away | W 63–43[4] | |
| 5 | March 1 | Chicago Rush | Home | L 13–40[5] | |
| 6 | March 8 | Tampa Bay Storm | Away | L 27–52[6] | |
| 7 | March 14 | San Jose SaberCats | Away | L 41–58[7] | |
| 8 | March 23 | Las Vegas Gladiators | Home | L 32–50[8] | |
| 9 | March 30 | Detroit Fury | Home | L 14–34[9] | |
| 10 | April 6 | New York Dragons | Away | W 46–39[10] | |
| 11 | April 11 | Orlando Predators | Away | L 23–66[11] | |
| 12 | April 18 | Los Angeles Avengers | Away | L 14–65[12] | |
| 13 | April 26 | Indiana Firebirds | Home | W 36–35[13] | |
| 14 | May 1 | Detroit Fury | Away | L 48–50[14] | |
| 15 | May 11 | New York Dragons | Home | L 30–49[15] | |
| 16 | May 18 | Las Vegas Gladiators | Away | L 38–55[16] |