The 2003–04 UEFA Cup first round was played from 24 September to 16 October 2003. The round consisted of 48 ties, with the winners advancing to the second round of the 2003–04 UEFA Cup.[1]
The draw was held on 29 August 2003, 13:00 CEST, at the Grimaldi Forum in Monaco. Teams were divided into geographical groups, each with seeded and unseeded pots.[2]
The first round featured the 41 winners of the qualifying round, joined by 36 directly qualified teams, the 16 losers of the Champions League third qualifying round and the 3 winners for the Intertoto Cup. The first legs were played on 24 and 25 September, and the second legs were played on 15 and 16 October 2003.
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2–2 on aggregate. Torpedo Moscow won 3–2 on penalty shootout.----Gaziantepspor won 1–0 on aggregate.----Groclin won 1–0 on aggregate.----1–1 on aggregate. Hajduk Split won on away goals.----Levski Sofia won 5–0 on aggregate.----Debrecen won 6–3 on aggregate.----Spartak Moscow won 3–1 on aggregate.----1–1 on aggregate. Vålerenga won on away goals.----Panionios won 3–1 on aggregate.----Slavia Prague won 4–2 on aggregate.----Roma won 5–1 on aggregate.----Utrecht won 6–0 on aggregate.----Rosenborg won 10–1 on aggregate.----Bordeaux won 3–2 on aggregate.----Steaua București won 2–1 on aggregate.----PAOK won 3–1 on aggregate.----Dnipro Dnipropetrovsk won 4–2 on aggregate.----Molde won 3–2 on aggregate.----Maccabi Haifa won 4–3 on aggregate.----Dinamo București won 5–2 on aggregate.----Villarreal won 3–2 on aggregate.----Sochaux won 3–0 on aggregate.----Basel won 3–2 on aggregate.----2–2 on aggregate. Copenhagen won 3–2 on penalty shootout.----Sporting CP won 3–0 on aggregate.----Dinamo Zagreb won 3–1 on aggregate.----Newcastle United won 6–0 on aggregate.----Heart of Midlothian won 2–0 on aggregate.----Auxerre won 2–0 on aggregate.----Red Star Belgrade won 6–5 on aggregate.----Aris won 3–2 on aggregate.----Borussia Dortmund won 3–1 on aggregate.----Manchester City won 4–2 on aggregate.----Wisła Kraków won 4–2 on aggregate.----Perugia won 3–1 on aggregate.----Lens won 6–0 on aggregate.----Parma won 4–1 on aggregate.----2–2 on aggregate. Austria Salzburg won on away goals.----Liverpool won 4–1 on aggregate.----Mallorca won 6–3 on aggregate.----Gençlerbirligi won 4–2 on aggregate.----Barcelona won 9–1 on aggregate.----Valencia won 2–0 on aggregate.----Benfica won 2–1 on aggregate.----Brøndby won 2–0 on aggregate.----Teplice won 3–1 on aggregate.----Feyenoord won 3–1 on aggregate.----Schalke 04 won 1–0 on aggregate.