See main article: article and 2001 US Open (tennis).
Arantxa Sánchez Vicario and Jared Palmer were the defending champions, but lost in the quarterfinals to Ai Sugiyama and Ellis Ferreira.
Rennae Stubbs and Todd Woodbridge won the title by defeating Lisa Raymond and Leander Paes 6–4, 5–7, [11–9] in the final.
This was the first US Open to introduce a super tie-break in lieu of the final tie-break set.